La investigación clínica es la actividad encaminada a conocer el resultado de una intervención o un producto para el diagnóstico o la terapéutica en los seres humanos. El ensayo clínico es el principal exponente de la investigación clínica y toda evaluación experimental de una sustancia o medicamento en seres humanos. En Cuba, existe un desarrollo importante de la biotecnología y de los centros de investigación que necesitan de ensayos clínicos según estándares nacionales e internacionales. En el presente trabajo se exponen (...) aspectos relacionados con la evolución histórica de la Investigación Clínica, el Ensayo Clínico y su contexto en el país como un primer acercamiento al tema. Clinical research is just that activity to know the potential diagnostic or therapeutic nature of an intervention or a product in humans. The clinical trial is the leading exponent of clinical research and the whole experimental evaluation of a substance or drug in humans and has revolutionized medical practice around the mundo.Sus precursors date back to the XVII and XVIII centuries and evolved since this methodology until the randomized controlled clinical trial. From the fifties significant regulatory and ethical changes appear. In Cuba, there is a significant development of biotechnology and research institutions that require clinical trials to national and international standards. This paper aims to clarify aspects of the historical development of Clinical Research, Clinical Trial in Cuba and its context as a first approach to the subject. (shrink)

WINNER OF THE SIMON HAILWOOD ESSAY PRIZE. This paper discusses the problem of alienation from nature, considered through the phenomena of reification and de-objectification. I propose understanding alienation as the result of a distorted relation between the subjective and the objective and I suggest a tentative solution via the combination of two ethico-political practices: releasement and reappropriation. In doing so, I put forward a structural-ethical critique and response to our current ecological crisis.

Modern individuals grapple with a paradoxical reality: their lives are characterized by a strong feeling of independence as well as by an intense social interconnection. This article argues that despite an increased discussion of dependence in contemporary social and political philosophy, current ways of theorizing it have disregarded the concrete form that our social dependence takes under capitalist relations. I maintain that without integrating the critique of political economy, we risk offering a defense of dependence that remains unaware of important (...) axes of domination. In particular, I suggest recuperating Marx’s notion of objective dependence, which has been insufficiently discussed in the existing literature. Finally, drawing on recent developments in critical theory, I put forward a normative critique of dependence. I contend that the issue with modern societies is that they promote alienated and reified relations of dependence, transforming the basis of our social freedom into an objective form of domination. -/- . (shrink)

Normative case studies are designed to offer richly detailed “worlds of possibility” that invite complex reflection and discussion about authentic ethical dilemmas in education. In this essay, Tatiana Geron and Meira Levinson argue that authors' choices of what details to include in a case are themselves ethical decisions that require significant ethical responsibility. Case details can shape which avenues of ethical inquiry are open to readers, whether and how institutional and structural conditions get considered, whose perspectives are included and (...) legitimized, and what political issues are understood as “open” or “closed.” At its best, case “world-building” can help readers understand the full complexity of ethical decision-making in education. However, for this to occur, case authors must seek out expert and dissenting perspectives, field test the case with diverse audiences, and remain reflexive about their own perspectives and how these shape their world-building decisions. (shrink)

In the treatise “Suprematism. The World as Objectlessness or Eternal Peace” (1922), Kazimir Malevich positions himself as a “bookless philosopher” who did not consider theories of other philosophers. In fact, the treatise contains a large number of references to philosophers belonging to different traditions. A careful reading shows the extent to which Malevich’s theory is linked to the Russian religious philosophy of the early twentieth century. In my view, Nikolai Berdyaev, Sergei Bulgakov, Pavel Florensky—philosophers of “Religious Renaissance,” as well as (...) some other intellectuals—acquaint avant-gardists with Neoplatonic conceptions of apophasis. Malevich had access to ideas of fourteenth-century theologian Meister Eckhart, and I will refer to two sources to demonstrate this, including Margarita Sabashnikova’s translation of Eckhart and works of Sergei Bulgakov. Without any reference, Malevich retells the concepts of Dionysius the Areopagite, Meister Eckhart, and Gregory Palamas. I will demonstrate parallels between the treatise on Suprematism and Meister Eckhart’s Sermons concerning the concepts of apophaticism, Platonism, and Nothingness. I will also touch on the theme of Divine Light in the theology of Palamas (fourteenth century) to show the diversity of the avant-garde’s sources of inspiration. (shrink)

El problema de la estetización y la reconfiguración de la experiencia en la filosofía de Walter Benjamin. Resumen de Tesis de Doctorado en Filosofía de Tatiana Staroselsky.

This article aims to make public part of the research on the concept of ‘light’ in the theological and, above all, liturgical tradition of the Greek Orthodox Church, based on its representation of the concept of ‘hypostasis’. Taking as a point of departure the interpretation of the expression ‘light of light’ [φῶς ἐκ φωτός (phôs ek phōtos)] of the text of the Niceno-Constantinopolitan Symbol, the article presents a proposal for the interpretation of the concept of ‘representation’ for this specific case, (...) based on the idea of apomímesis, and applies this concept to a reading of the place of ‘light’ in the Holy Scripture, in the Patrology and in the Greek Eastern Liturgies. (shrink)

In lieu of an abstract, here is a brief excerpt of the content:418 Feminist Studies 43, no. 2. © 2017 by the estate of tatiana de la tierra. Ode to Unsavory Lesbians i love an ugly lesbian one who walks with a limp talks with a lisp leaves her dentures out overnight by the bathroom sink wears polyester pants and men’s cologne, the cheap kind has a beard so long she steps on it sprouts warts on her toes, all (...) twelve of them carries a spittoon in her breast pocket chortles at church people i dream of a lesbian who’s always broke she doesn’t own a car, walks streets barefoot, near and far washes all her clothes by hand steals from walmart scams the business-suited man lights matches on her wooden leg barbeques freshly plucked birds on her shopping cart seasons them with salt, that’s all licks her fingers in the moonlight i crave a lesbian who’s fat and fleshy so big she can’t fit through the door at starbucks and they set up an outdoor café just for her so fat she wears bangles on her fingers her belly is a boom box her stretch marks are hieroglyphic etchings she’s so heavy, tectonic plates shift beneath her feet so huge, lake erie is her bathtub tatiana de la tierra tatiana de la tierra   419 i lust after an unsavory lesbian she blows away my lackluster day leads me in a lambada, lights lantern between my legs lays my head down on lace pillows humps me like a lamppost lacerates me with leather lust lacquers my body with blue latex paint logs the forest for prime wood builds me lakeside throne sets me there and worships me —goddess in blue— lines my path with lady slippers ravishes me with sex words pets me like a little lamb wins me by a landslide To My Kidneys i had no inkling of your existence those summers when i swam in waters at the turkey point nuclear power plant a mile from home was proud of the organic salad tomatoes and the steaming peppermint tea that came from backyard garden a block from the rex chemicals plant life at 29822 SW 147th avenue in leisure city was anything but leisurely 420 tatiana de la tierra it was all screaming and fighting and cursing hijueputa this and hijueputa that poverty pissed me off i drank too much high fructose corn syrup not enough purified water snorted cocaine smoked dope lived all toughed out while you worked silently on my behalf filtering purifying regulating i was an angry girl but i blew up no buildings killed no one i was all hot air exploding inside letting carnage settle harden at twenty-nine something was wrong the damage was done your tubules were atrophying glomeruli were dead and dying you were inflamed and irate i had twenty-four grams of protein in the urine all swollen and freakishly feverish pouring my fluids into vials and beakers tried to recollect every sun burn those little red dots on my childhood skin tatiana de la tierra   421 i was a medical mystery for months until the day doctors made a diagnosis: lupus-mediated membranous glomerulonephritis now, eighteen years later you’re all i’ve got my future is in the capillaries of your glomeruli i’ve taken pills done prayers of all kinds even injected myself with german baby’s umbilical cord to keep you going yet you falter healers put the blame on all kinds of things deep-seated fears petrochemicals lead cadmium karma white flour self-hatred seriousness we’re in this together, you and i let’s go get sunshine drink green tea grow tall and strong wade in waters up to our knees like the cypress in the florida swamps gracing riverbanks and wetlands roots filtering flowing waters branches stretching to the skies with their durable and eternal woods 422 tatiana de la tierra Topanga Canyon i had forgotten trees how they claim earth and sky a herd of elephants standing in place reaching up with their trunks carrying torches of green leaves that breathe after death crushed at my feet trees splayed out like spent lovers legs open... (shrink)

In the paper the joint Logic of Proofs and Provability is presented that incorporates both the modality □ for provability 287–304) and the proof operator tF representing the proof predicate “t is a proof of F” . The obtained system naturally includes both the modal logic of provability GL and Artemov's Logic of Proofs . The presence of the modality □ requires two new operations on proofs that together with operations of allow to realize all the invariant operations on proofs (...) admitting description in the modal propositional language. Logic is proved to be decidable and complete with the intended provability semantics. (shrink)

The Russian people are struggling to learn how to create a democracy and a market economy. This paper reviews the results of reform efforts to date and what the Russian people are learning as indicated by changes in answers to public opinion surveys. As a way to continue the social learning process in Russia we suggest the widespread use of process improvement methods in organizations. This paper describes some Russian experiences in using process improvement methods and proposes a strategy for (...) spreading the use of these methods through universities and then through businesses and government agencies. As people use process improvement methods, they gain confidence in their ability to improve the functioning of organizations and society. (shrink)

:This article reexamines the “prostitution objection” to paid surrogacy, and argues that rebuttals to this objection fail to focus on surrogates as embodied persons. This failure is based on the false distinction between “selling one’s reproductive services” and “selling one’s body.” To ground the analysis of humans as embodied persons, this article uses Kant’s late ethical theory, which develops the conceptual framework for understanding human beings as embodied selves. Literature on surrogacy commonly emphasizes that all Kantian duties heed to the (...) categorical prohibition to treat persons as mere means. What this literature leaves out is that this imperative commands us more specifically to engage ourselves and others as embodied persons. This article aims to relate this point to a specific issue in assisted reproduction. It argues that a Kantian account of human beings as embodied persons prohibits paid surrogacy on exactly the same grounds as it prohibits prostitution. (shrink)

The relevance of the topic of research of humanitarian capital as a set of values of social sciences today plays an exceptional role, because human capital is a great character and its goal is the process of mastering the world through the development of humanistic knowledge and methods of cultural education, aimed at personality formation. The Central problem for modern conditions is management education with a view that human capital formed by all humanist-oriented sciences, must be directed to the development (...) and fulfillment of personality. The main task of higher school is the identification, preservation and effective use of human knowledge as a set of humanistic values, which together constitute the human capital needed to ensure a comprehensive and creative personality. The article explains the essence, objectives and main directions of human capital with the aim to form comprehensive and creative personality, based on cultural development of man as his self-development and self-actualization. Objectives of the study are the conceptualization of human capital as a set of humanitarian values, which are implemented in practice of educational process of higher school. The methodological basis for the formation of humanitarian capital in the information society is a synergetic methodology aimed at revealing the intellectual and creative personality, which incorporates all the values of the Humanities, presented by specific synergistic tools. Conclusions – management of education in modern conditions should be directed on formation of mechanisms of human capital as a set of values created by mankind and implemented by social sciences and disciplines. (shrink)

The two-fold image as Dostoevsky’s creative principle has been repeatedly observed and described from different perspectives in accordance with different research tasks. In this article, attention will be focused on the description of the two-fold image, its structure and functions, by Dostoevsky himself within the framework of his reflection on his creative method, as part of what can be called his own theory of creativity. In 1876, Dostoevsky describes the structure of a two-fold image from three different angles on three (...) occasions over a short period of time: from the point of view of the structure as such; from the point of view of its manifestation and revelation in a work of fiction; from the point of view of its application as a working construct in a particular case for a particular person. Dostoevsky understands the two-fold image as a profound insight about the world and man, a fundamental philosophy of personality that provides the reader with clues to a personal transformation. At the same time, he always speaks about the second component of the image absolutely transparently to himself—but covertly to the reader, assuming that it is the enigmatic nature of its deep core that compels the reader to look at and listen to the implicit concept, making the image a working, transforming tool. (shrink)

The article highlights the issues of modeling processes of a socio-economic nature, considers the problems and reveals the factors influencing the construction of the model algorithm. In our opinion, studies of economic processes undoubtedly affect the social side of the development of the territory. The scientific novelty lies in the development and testing of new approaches to the construction of a model that allows us to systematically characterize the processes taking place, based on the analysis of the whole, territorial development, (...) in relation to the structure of its parts, including human capital, which will make it possible to create a mechanism that ensures maneuverability in order to effectively use the potential of the region. As a result, an assessment of the current state of affairs for a certain subject of the Russian Federation is given, but some aspects touched upon in the study require an additional information block. The considered structural factors are determined in the share influence, which allows us to conclude about the regulation of processes with external and internal influence. (shrink)

The authors of the article consider the main directions of the development of choral culture of the twentieth century in the context of domestic and regional socio-cultural processes through the prism of the legacy of the multifaceted creative personality of A. S. Anokhin, as well as through the analysis of the biography and creative path of the composer, based on his diaries and memoirs; presenting his views on the historical events of that time from the point of view of the (...) musician and a teacher. The figure of Afanasy Stepanovich Anokhin is one of the key figures in the musical education and enlightenment of the Altai Territory in the XX century, about his creative and educational activities. The novelty of the research lies in the reconstruction of the integral creative image of the composer in the context of the formation of musical culture in the Soviet period in the Altai Territory. In this work, for the first time, a complete list of the composer's published works is published. A. S. Anokhin's main compositional legacy is connected with mass songwriting, one of the most popular genres of the Soviet era. The article also examines the development of musical and choral culture in the Altai Territory from amateur groups to professional performance and the development of musical education throughout the twentieth century, as well as raises issues of preservation and reclamation of regional cultural heritage. (shrink)

The Hyperuniverse Program is a new approach to set-theoretic truth which is based on justifiable principles and leads to the resolution of many questions independent from ZFC. The purpose of this paper is to present this program, to illustrate its mathematical content and implications, and to discuss its philosophical assumptions.

Disgust and Intimacy The aim of the paper is to present the results of preliminary research into the relation between disgust and intimacy. The authors apply current psychological conceptions of the emotions relating to social behaviour, primarily the theory of disgust associated with Paul Rozin, Jonathan Haidt and Clark McCauley. The research was conducted in a community of students living in student halls in Bratislava. The authors argue that social relationships may influence expressions of core disgust and the animal-nature disgust (...) that is considered to be an earlier stage in the evolutionary development of this emotion. More specifically, people's representations of feelings of disgust towards elicitors linked to certain persons are conditioned by the social categories those persons belong to and the socio-cultural schemas distributed in the given environment. (shrink)

Reflete-se aqui sobre o papel da Universidade na atual sociedade capitalista. Elateria a capacidade de difundir a concepção de mundo das classes trabalhadoras, contribuindo para a construção de uma outra sociedade, ou ela seria mais um instrumento de reprodução das sociedades capitalistas Existe um conflito contínuo entre essas duas propostas, que se tenta apresentar com base na discussão gramsciana sobre seus conceitos fundamentais, buscando-se compreender a realidade brasileira atual neste contexto. Procura-se também abordar o debate sobre a Universidade no Brasil, (...) analisando-se em que medida seria possível uma atuação transformadora da realidade social por parte desta instituição.This article presents a reflection on the University in a capitalist society. It would have the capacity to spread out the conception of world of the diligent classrooms, contributing for the construction of one another society, or it would be an instrument of reproduction of the capitalist society? There’s a conflict between these two distinct proposals, and I try to present this movement by using the Gramsci’s concepts, understanding the current Brazilian reality in this context. I also try to present the current debate on the University in Brazil, trying to understand if it’s possible to the University to transform the social reality. (shrink)

In social interactions, emotional biases can arise when the emotional state of oneself and another person are incongruent. A person’s ability to judge the other’s emotional state can then be biased by their own emotional state, leading to an emotional egocentric bias (EEB). Alternatively, a person’s perception of their own emotional state can be biased by the other’s emotional state leading to an emotional altercentric bias (EAB). Using a modified audiovisual paradigm, we examined in three studies (n = 171; two (...) online & one lab-based study) whether emotional biases can be considered traits by measuring two timepoints within participant and relating empathy trait scores to emotional biases, as well as the electrophysiological correlates of emotional biases. In all studies, we found a congruency effect, reflecting an EEB and EAB of small size. Both biases failed to correlate significantly within participants across timepoints and did not display significant relationships with empathy trait scores. On the electrophysiological level, we did not find any neural emotional bias effects in the time–frequency domain. Our results suggest that EEB and EAB effects are strongly task sensitive. Caution is warranted when studying interindividual differences in emotional biases using this paradigm, as they did not show significant test-retest reliabilities. (shrink)

Introduction. The condition of fixed assets and their rational management largely determine the competitiveness of an enterprise. Updating the production base is possible both at the expense of their own funds and at the expense of borrowed funds. When choosing sources of financing for renovating fixed assets, it is important to assess the impact of the chosen acquisition method on cash flows and the financial result of an enterprise. The purpose of the article is to assess the impact of the (...) chosen method of financing the acquisition of fixed assets on the company’s financial results and cash flow. Methods. Comparison, induction, analysis, synthesis, direct counting, the author’s methodology for assessing the impact of the source of renovation on the financial result of the enterprise and cash flow. Scientific novelty of the research. The authors propose an additional criterion for assessing the efficiency of managing fixed assets of an enterprise: choosing the most optimal method of acquisition, based on assessing its impact on the financial results of activities, and they also proposed to supplement the options for renovating the main environments using leases, since, depending on the economic situation, this option may have financial advantages over credit, loan and leasing. Results. The authors predict the influence of the method of financing the acquisition of fixed assets (credit, leasing, rent, own funds) on the financial result of an enterprise and cash flows; develop the general approaches to the method of choosing the optimal source of financing for the renovation of fixed assets. Conclusions. The acquisition of ownership of fixed-capital assets is not always advisable. The article shows that not only credit or leasing operations, but also rent are comparable in efficiency. When choosing a source of financing for renovating fixed assets, it is necessary to compare the costs of acquiring property and their distribution by periods, to analyze the impact of the method of acquiring them on the financial result of the enterprise and cash flow. (shrink)

Rethinking philosophy of history we see that the main concepts must be revised or specified especially and. It’s very important to use adequate notions. The world history is an integral process having dialectically contradictory tendencies. Humanism is an objective tendency of the world history but the alienated tendency prevails in the epoch of globalization. Collisions between civilizations are outcomes of the alienated capitalist world system. Many problems both in practice and in theory are connected with a fortune of humanism and (...) a problem of mutual understanding between representatives of different cultures is among them. So philosophy of history must be revised in humanistic way and we must do our best to put the humanistic tendency into practice. (shrink)

The article assumes that the search for legitimacy (politics) and the demand for public governance efficiency and effectiveness (policies) are closely intertwined and cannot be separated either structurally or substantively. The legitimacy of policies is not simply a consequence of the legitimacy of political power, but is created by bringing stakeholders together in the process of policy making and implementing. Therefor policy needs to be managed in order to restrict unpredictability when formulating and implementing collective choices. We argue that the (...) policy initiator should act as policy manager binding the whole process from the idea to the results. (shrink)

Revisiting the generally accepted notion of psycho-physical parallelism in Spinoza, Chantal Jaquet offers a new analysis of the relation between body and mind. Looking at a range of Spinoza's texts, and using an original methodology, she analyses their unity in action through affects, actions and passions.

Este artículo explora la problemática del cuerpo desde una perspectiva de género. Primero, se estudia la evasión filosófica del cuerpo, así como su inadvertida asimilación a lo femenino. Segundo, se examina la negación capitalista del cuerpo y la posibilidad de entender la diferenciación entre las lógicas de explotación y de expropiación a través de una previa diferenciación entre cuerpos. Se propone finalmente hacer un análisis de la exclusión general del cuerpo como una exclusión particular de lo femenino y de lo (...) popular y se sugiere que el advenimiento de los cuerpos promulgado desde el movimiento feminista, especialmente en su vertiente latinoamericana, traen consigo un potencial democrático y emancipador. (shrink)

Logic of proofs LP was introduced by S. Artemov in. It describes properties of the proof predicate “t is a proof of F” formalized by the formula ⟦t⟧ F. Proofs are represented by terms constructed by three elementary recursive operations on proofs. In this paper we extend the language of the logic of proofs by the additional storage predicate x ∋ F with the intended interpretation “x is a label for F”. The storage predicate can play the role of syntax (...) encoding, so it is useful for specification of operations on proofs, especially those that require formula arguments. We give a definition of a specification of an operation on proofs and introduce logics that describe such operations. For a large class of operations we prove the completeness of these logics with respect to the intended semantics. We also study the logic describing the operation of substitution. (shrink)

The article explores court forms as an interactive genre essential for legal-lay communication in civil and family proceedings: court forms elicit key information from predominantly lay users for the purposes of court administration and the judiciary. The information presented in court forms defines the agenda and communicative focus of the subsequent hearings and settlement negotiations, and in some instances even the path the proceedings would take. It is thus important to consider court forms in terms of their comprehensibility as well (...) as functionality for eliciting legally coherent narratives and facilitating efficient engagement of lay participants with the proceedings. The case study presented in the article draws on the combination of corpus linguistics and discourse analysis to explore two versions of the court form most frequently used by self-represented parties in England and Wales, ‘Form C100: Apply for a court order to make arrangements for a child or resolve a dispute about their upbringing’. The comparison of the paper form and its redesigned online version identifies the improvements made as part of the digitisation process but also indicates communicative challenges which can prevent the lay person from presenting the relevant information. The discussion provides an opportunity to reflect on the role of language in online courts. (shrink)

As part of the response to the COVID-19 pandemic, many jurisdictions across the world introduced remote hearings as an alternative way of continuing to offer access to courts. This practice-based article discusses the report prepared by the author for a judicial review case which revolved around the claim that in immigration settings the quality of interpreting conducted in fully online hearings is inferior to interpreting in face-to-face hearings. In the absence of pre-existing research comparing the impact of the physical and (...) fully online settings on interpreting, the author’s expert witness report explored linguistic principles governing conversation and turn-taking management, power relations and narrativisation and discursive practices in online and physical settings to illustrate communicative advantages and disadvantages of each environment. The article draws on the investigations conducted for the expert witness report and pursues the following aims: (1) reflect on the role of linguistic expertise required for the case; (2) detail the conclusions drawn and recommendations endorsed in the report; (3) discuss the importance of effective communication in immigration settings; (4) challenge common misconceptions in relation to how narratives are elicited, shared and perceived; (5) explore safeguarding strategies for enhancing discursive practices in fully remote hearings in order to improve non-native speakers’ access to justice. (shrink)

Orphaned in her early teens and shuttled between abusive foster homes, Tatiana Forero Puerta found herself in her early twenties in New York City, haunted by the memories of her tumultuous youth and suicidal. Following emergency hospitalization, she was advised by her doctor to take up yoga. Over days, weeks, months, and then years, she embraced yoga's honesty and discipline--delving more deeply into its wisdom, literature, and, vitally, its practice. In so doing, yoga healed her scars, opened her soul (...) to forgiveness, and allowed her to reconcile herself with a past that had threatened to snuff out her life. Yoga for the Wounded Heart is an unsparingly honest memoir of a childhood lost and of courage and resilience gained. It's also an exploration of the fundamentals of yoga: as a technology that focuses our awareness; as a practical application of mindfulness and attention to what is really going on in our lives and bodies; and as a vehicle for the body to guide the mind and heart toward healing. (shrink)